This gene is a member of the myosin gene family. Myosins are mechanochemical proteins characterized by the presence of a motor domain, an actin-binding domain, a neck domain that interacts with other proteins, and a tail domain that serves as an anchor. This gene encodes an unconventional myosin with a very short tail. Defects in this gene are associated with the mouse shaker-1 phenotype and the human Usher syndrome 1B which are characterized by deafness, reduced vestibular function, and (in human) retinal degeneration. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008]
Alternative Names
DFNB2 MYU7A NSRD2 USH1B DFNA11 MYOVIIA
Molecular Weight(MW)
254 kDa
Cellular Localization
Cytoplasm,Cytoskeleton,Synapse
Application
WB
Western blot analysis of extracts from Y-79 cells using MYO7A Rabbit mAb at 1:1000.
Application Notes
WB:1:1000-1:5000
Additional Information
Form
Liquid
Storage Instructions
Store at -20°C.Stable for 12 months from date of receipt.
Storage Buffer
Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA