Application
Western blot analysis of NALP7 in human brain tissue lysate with NALP7 antibody at 1 ug/ml in (A) the absence and (B) the presence of blocking peptide.Application
Immunofluorescence of NALP7 in human brain tissue with NALP7 antibody at 20 μg/mL.Application
Immunohistochemistry of NALP7 in human brain tissue with NALP7 antibody at 10 μg/mL.| Product Name | NALP7 antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | Rabbit polyclonal antibody to NALP7NOD proteins include the apoptosis regulator APAF1 (apoptotic protease activating factor 1) and mammalian NOD-LRR proteins. NALP7, also known as PYPAF3, a member of the related PYRIN-containing APAF1-like proteins (PYPAFs/NALPs) is thought to play a crucial role in cell proliferation. NALP7 has a C-terminal leucine-rich repeat (LRR) region, an N-terminal Pyrin domain (PYD) followed by a NACHT domain, and a NACHT-associated domain. It is expressed in numerous tissues including uterus and ovary, with low levels in heart and brain. NALP7 inhibits caspase-1-dependent interleukin-1beta secretion and is a feedback regulator of interleukin-1beta secretion. Defects in the NALP7 gene are known to cause the formation of a hydatidiform mole (HYDM) and reduce the growth of carcinoma cell lines. |
| Clonality | Polyclonal |
|---|---|
| Host Species | Rabbit |
| Tested Applications | ELISAICC/IFIHC-PWB |
| ICC/IF:1:200~1:500 IHC-P:1:50~1:200 WB:1:500~1:2000 Notes:Optimal dilutions/concentrations should be determined by the researcher. |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Synonyms | PYPAF3 NLR family pyrin domain containing7 PYRINcontaining APAF1like protein 3 CLR19.4 NLRP7 PYRINcontaining APAF1like protein3 NALP7 HYDM PAN7 NLR family pyrin domain containing 7 NOD12 PYRIN-containing APAF1-like protein 3 |
|---|---|
| Target | NALP7 |
| Tissue Specificity | This antibody is specific for NALP7 |
Application
Western blot analysis of NALP7 in human brain tissue lysate with NALP7 antibody at 1 ug/ml in (A) the absence and (B) the presence of blocking peptide.
Application
Immunofluorescence of NALP7 in human brain tissue with NALP7 antibody at 20 μg/mL.
Application
Immunohistochemistry of NALP7 in human brain tissue with NALP7 antibody at 10 μg/mL.| Positive Control | Blocking Peptide: |
|---|---|
| Application Notes | ICC/IF:1:200~1:500 IHC-P:1:50~1:200 WB:1:500~1:2000 Notes:Optimal dilutions/concentrations should be determined by the researcher. |
| Form | Liquid |
|---|---|
| Storage Instructions | Keep as concentrated solution. Aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | PBS containing 0.02% sodium azide |
