Rabbit Polyclonal antibody to Nav1.8The protein encoded by this gene is a tetrodotoxin-resistant voltage-gated sodium channel alpha subunit. The properties of the channel formed by the encoded transmembrane protein can be altered by interaction with different beta subunits. This protein may be involved in the onset of pain associated with peripheral neuropathy. [provided by RefSeq, Dec 2011]
Immunogen
Peptide (C)EDEVAAKEGNSPGPQ, corresponding to amino acid residues 1943-1956 of rat Nav1.8 (Accession Q63554). Intracellular, C-terminus.
Key Feature
Clonality
Polyclonal
Host Species
Rabbit
Tested Applications
ICC/IFIHCIPWB
ICC/IF:1:200~1:500 IHC:1:50~1:200 IP:1:100~1:500 WB:1:500~1:2000 Notes:Optimal dilutions/concentrations should be determined by the researcher.
Species Reactivity
HumanRat
Concentration
1mg/ml
Purification
Affinity purified
Target Information
Gene Synonyms
PN3 SCN10A SNS hPN3 sodium channel voltage-gated type X alpha subunit
Target
Nav1.8
Application
Application
IHC analysis of rat DRG using Nav1.8 antibody (red) and Neurofilament 200 antibody (green).
Application
WB analysis of rat DRG lysates using Nav1.8 antibody at a dilution of 1:200 in the (1) absence or (2) presence of blocking peptide.
Application Notes
ICC/IF:1:200~1:500 IHC:1:50~1:200 IP:1:100~1:500 WB:1:500~1:2000 Notes:Optimal dilutions/concentrations should be determined by the researcher.
Additional Information
Form
Liquid
Storage Instructions
Keep as concentrated solution. Aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.