| Product Name | NF-H + NF-L antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | Mouse Monoclonal antibody [2F11] to NF-H + NF-LNeurofilaments are type IV intermediate filament heteropolymers composed of light, medium, and heavy chains. Neurofilaments comprise the axoskeleton and they functionally maintain the neuronal caliber. They may also play a role in intracellular transport to axons and dendrites. This gene encodes the light chain neurofilament protein. Mutations in this gene cause Charcot-Marie-Tooth disease types 1F (CMT1F) and 2E (CMT2E), disorders of the peripheral nervous system that are characterized by distinct neuropathies. A pseudogene has been identified on chromosome Y. [provided by RefSeq, Oct 2008] |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG1 |
| Clone Number | 2F11 |
| Host Species | Mouse |
| Tested Applications | IHC-FIHC-P |
| Immunohistology - Frozen: Max Dilution 1/40: |
|
| Species Reactivity | HumanMouseDogRatPrimate |
| Concentration | 1mg/ml |
| Gene Synonyms | NF68 NEFL CMT2E NFL CMT1F NF-L |
|---|---|
| Target | NF-H + NF-L |
| Tissue Specificity | This antibody recognizes human brain neurofilaments of 70kDa and 200kD. |
| Application Notes | Immunohistology - Frozen: Max Dilution 1/40: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Store at +4°C or at -20°C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use. |
| Storage Buffer | Phosphate buffered saline containing 0.1% Sodium Azide (NaN3) 1% Bovine Serum Albumin |
