Application
NFkB p100/p52 antibody [N1N3] detects NFKB2 protein at cytoplasm in rat thymus by immunohistochemical analysis. Sample: Paraffin-embedded rat lymph node. NFkB p100/p52 antibody [N1N3] diluted at 1:500.| Product Name | NFkB p100/p52 antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | Rabbit polyclonal antibody to Nuclear factor NF-kappa-B p100 subunit (nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100))NFKB has been detected in numerous cell types that express cytokines, chemokines, growth factors, cell adhesion molecules, and some acute phase proteins in health and in various disease states. NFKB is activated by a wide variety of stimuli such as cytokines, oxidant-free radicals, inhaled particles, ultraviolet irradiation, and bacterial or viral products. Inappropriate activation of NF-kappa-B has been linked to inflammatory events associated with autoimmune arthritis, asthma, septic shock, lung fibrosis, glomerulonephritis, atherosclerosis, and AIDS. In contrast, complete and persistent inhibition of NF-kappa-B has been linked directly to apoptosis, inappropriate immune cell development, and delayed cell growth. For reviews, see Chen et al. (1999) [PubMed 9895331] and Baldwin (1996) [PubMed 8717528].[supplied by OMIM] |
| Immunogen | Recombinant protein encompassing a sequence within the center region of human NFkB p100/p52. The exact sequence is proprietary. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | IHC-PWB |
| *Optimal dilutions/concentrations should be determined by the researcher.
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| Predicted Reactivity | Human, Mouse, Rat, Chicken, BovineHuman (100%), Mouse (98%), Rat (98%), Chicken (85%), Bovine (98%) |
| Concentration | 1mg/ml (Please refer to the vial label for the specific concentration) |
| Purification | Affinity purified |
| Gene Synonyms | LYT-10 antibody LYT10 antibody p52 antibody NFKB2 antibody nuclear factor NF-kappa-B p100 subunit antibody nuclear factor of kappa light chain gene enhancer in B-cells 2 antibody oncogene Lyt-10 antibody DNA-binding factor KBF2 antibody lymphocyte |
|---|---|
| Target | Nuclear factor NF-kappa-B p100 subunit |
| Molecular Weight(MW) | 97 kDa (note) |
| Cellular Localization | Nucleus , Cytoplasm |
Application
NFkB p100/p52 antibody [N1N3] detects NFKB2 protein at cytoplasm in rat thymus by immunohistochemical analysis. Sample: Paraffin-embedded rat lymph node. NFkB p100/p52 antibody [N1N3] diluted at 1:500.| Positive Control | Target recombinant protein |
|---|---|
| Application Notes | *Optimal dilutions/concentrations should be determined by the researcher.
: |
| Form | Liquid |
|---|---|
| Storage Instructions | Keep as concentrated solution. Aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | 0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative. |
