| Product Name | NOX2 / gp91phox antibody [54.1] |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | Mouse Monoclonal antibody [54.1] to NOX2/gp91phoxCytochrome b (-245) is composed of cytochrome b alpha (CYBA) and beta (CYBB) chain. It has been proposed as a primary component of the microbicidal oxidase system of phagocytes. CYBB deficiency is one of five described biochemical defects associated with chronic granulomatous disease (CGD). In this disorder, there is decreased activity of phagocyte NADPH oxidase; neutrophils are able to phagocytize bacteria but cannot kill them in the phagocytic vacuoles. The cause of the killing defect is an inability to increase the cell's respiration and consequent failure to deliver activated oxygen into the phagocytic vacuole. [provided by RefSeq] |
| Immunogen | Partially Purified human neutrophil flavocytochrome b (heparin Ultrogel/lectin affinity purification in Triton X-100) |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG1 |
| Clone Number | 54.1 |
| Host Species | Mouse |
| Tested Applications | WB |
| For WB: Use at 1:1000 | |
| Species Reactivity | Human |
| Concentration | 1mg/ml (Please refer to the vial label for the specific concentration) |
| Purification | Protein G |
| Gene Synonyms | CGD, GP91-1, GP91-PHOX, GP91PHOX, NOX2 |
|---|---|
| Target | NOX2/gp91phox |
| Tissue Specificity | NOX2/gp91phox 382-PKIAVDGP-389 |
| Application Notes | For WB: Use at 1:1000 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Store at 2-8°C. For extended storage, aliquot and store at -20°C. Avoid repeated freeze-thaw cycles. |
| Storage Buffer | PBS + 0.1% sodium azide |
