Application
Sample (50 ug of whole cell lysate) A: mouse liver 12% SDS PAGE diluted at 1:1000| Product Name | NR1I3 antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | Rabbit Polyclonal antibody to NR1I3 (nuclear receptor subfamily 1, group I, member 3)This gene encodes a member of the nuclear receptor superfamily, and is a key regulator of xenobiotic and endobiotic metabolism. The protein binds to DNA as a monomer or a heterodimer with the retinoid X receptor and regulates the transcription of target genes involved in drug metabolism and bilirubin clearance, such as cytochrome P450 family members. Unlike most nuclear receptors, this transcriptional regulator is constitutively active in the absence of ligand but is regulated by both agonists and inverse agonists. Ligand binding results in translocation of this protein to the nucleus, where it activates or represses target gene transcription. These ligands include bilirubin, a variety of foreign compounds, steroid hormones, and prescription drugs. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq] |
| Immunogen | Recombinant protein encompassing a sequence within the center region of human NR1I3. The exact sequence is proprietary. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WB |
| *Optimal dilutions/concentrations should be determined by the researcher.
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| Species Reactivity | Mouse |
| Predicted Reactivity | Human, Rhesus Monkey, ChimpanzeeHuman (100%), Rhesus Monkey (92%), Chimpanzee (96%) |
| Concentration | 1mg/ml (Please refer to the vial label for the specific concentration) |
| Purification | Affinity purified |
| Gene Synonyms | CAR antibody CAR1 antibody MB67 antibody MGC150433 antibody MGC97144 antibody MGC97209 antibody NR1I3 antibody constitutive androstane nuclear receptor variant 2 antibody constitutive androstane nuclear receptor variant 3 antibody nuclear receptor |
|---|---|
| Molecular Weight(MW) | 40 kDa (note) (8) |
| Cellular Localization | Nucleus |
Application
Sample (50 ug of whole cell lysate) A: mouse liver 12% SDS PAGE diluted at 1:1000| Positive Control | mouse liver |
|---|---|
| Application Notes | *Optimal dilutions/concentrations should be determined by the researcher.
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| Form | Liquid |
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| Storage Instructions | Keep as concentrated solution. Aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | 1XPBS, 1% BSA, 20% Glycerol (pH7). 0.01% Thimerosal was added as a preservative. |
