| Product Name | Ornithine Decarboxylase antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | Mouse monoclonal [3F293] to Ornithine DecarboxylaseOrnithine Decarboxylase (ODC) is the initial and rate limiting enzyme in the biosynthetic pathway of polyamines and is involved in the conversion of ornithine to putrescine. The biological activity of ODC is rapidly induced in response to virtually all agents known to promote cell proliferation including hormones, drugs, growth factors, mitogens, and tumor promoters. Reportedly, ODC mRNA levels are elevated in lung carcinomas as well as in colon adenomas and carcinomas. ODC activity in colorectal carcinomas is greater than those in adenomas and normal mucosa. |
| Immunogen | A synthetic hexadecapeptide (KPDEKYYSSSIWGPTC), corresponding to amino acids 345-360 from rat ODC. |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG1 |
| Clone Number | 3F293 |
| Host Species | Mouse |
| Tested Applications | IHC-F |
| Not recommended for use in Western blotting. IHC-Fr: Use at an assay dependent dilution. Optimal dilutions/concentrations should be determined by the end user.: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml (Please refer to the vial label for the specific concentration) |
| Purification | Protein G |
| Gene Synonyms | Odc RGD1562933 |
|---|---|
| Target | Ornithine Decarboxylase |
| Tissue Specificity | Recognizes the native ODC and not the inhibited (labeled with H3-DFMO) enzyme. |
| Cellular Localization | Cytoplasmic |
| Positive Control | Epithelial cells in normal placenta or prostate carcinoma |
|---|---|
| Application Notes | Not recommended for use in Western blotting. IHC-Fr: Use at an assay dependent dilution. Optimal dilutions/concentrations should be determined by the end user.: |
| Form | Liquid |
|---|---|
| Storage Instructions | Keep as concentrated solution. Store at 4°C short term. For extended storage aliquot and store at -20°C or below. Avoid freeze-thaw cycles. |
| Storage Buffer | Preservative: NoneConstituents: 10mM PBS. pH 7.4 |
