Rabbit Polyclonal antibody to PAI-1This gene encodes a member of the serine proteinase inhibitor (serpin) superfamily. This member is the principal inhibitor of tissue plasminogen activator (tPA) and urokinase (uPA), and hence is an inhibitor of fibrinolysis. Defects in this gene are the cause of plasminogen activator inhibitor-1 deficiency (PAI-1 deficiency), and high concentrations of the gene product are associated with thrombophilia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]
Immunogen
Recombinant protein of human SERPINE1
Key Feature
Clonality
Polyclonal
Isotype
IgG
Host Species
Rabbit
Tested Applications
IHC-PWB
WB: 1:500 - 1:2000, IHC: 1:50 - 1:200:
Species Reactivity
HumanMouseRat
Concentration
1mg/ml
Purification
Affinity purified
Target Information
Gene Synonyms
PAI PLANH1 PAI1 serpin peptidase inhibitor clade E (nexin plasminogen activator inhibitor type 1) member 1 SERPINE1
Target
PAI-1
Application
Application
Western blot analysis of extracts of A549 cell line, using SERPINE1 antibody.