Application
Western blot analysis of pan-shank in rat brain membrane lysates using a 1:1000 dilution of| Product Name | PAN-SHANK antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | Mouse monoclonal antibody [S23b-49] to PAN-SHANKSeems to be an adapter protein in the postsynaptic density (PSD) of excitatory synapses that interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors, and the actin-based cytoskeleton. May play a role in the structural and functional organization of the dendritic spine and synaptic junction. |
| Immunogen | Fusion protein amino acids 84-309 of rat Shank2; accession number Q9QX74 |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG1 |
| Clone Number | S23b-49 |
| Host Species | Mouse |
| Tested Applications | IHCIPWB |
| We recommend a working dilution of 1-10ug/mL (WB), 0.1-1.0ug/mL (Perox) (IHC/ICC), 1.0-10ug/mL (IF).: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml (Please refer to the vial label for the specific concentration) |
| Purification | Protein G |
| Target | PAN-SHANK |
|---|---|
| Molecular Weight(MW) | 160kDa (note) |
| Tissue Specificity | Recognzies Shank1, 2 and 3. |
| Cellular Localization | Cytoplasm, postsynaptic density of neuronal cells. Colocalizes with cortactin in growth cones in differentiating hippocampal neurons. |
Application
Western blot analysis of pan-shank in rat brain membrane lysates using a 1:1000 dilution of| Application Notes | We recommend a working dilution of 1-10ug/mL (WB), 0.1-1.0ug/mL (Perox) (IHC/ICC), 1.0-10ug/mL (IF).: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Aliquot and store at -20 C. Avoid repeated freeze-thaw cycles. |
| Storage Buffer | PBS pH7.4, 50% glycerol |
