| Product description |
Mouse anti-Phosphotyrosine (2-105) monoclonal antibodySince the discovery that pp60src phosphorylates both itself as well as a number of cellular proteins on tyrosyl residues, the family of genes known to encode protein-tyrosine kinases has expanded. This family of proteins is now known to include additional oncogenes such as fes, fms, and abl as well as a number of cellular receptors for ligands such as EGF/TGFa, PDGF, somatomedin C, and insulin. Phosphorylation of proteins is a key regulatory event that controls all aspects of signal transduction, the cell cycle and the apoptotic process. Phosphorylation is not restricted to tyrosine residues but may also occur on serine and threonine residues as well. A separate family of serine/threonine kinases mediates this latter modification. Phosphorylation of the growth factor receptor proteins and other proteins has been shown to be closely involved in normal as well as abnormal cellular proliferative responses, the immune response as well as many other biological and physiological pathways. Monoclonal antibodies specific for phosphotyrosine residues may be used for the characterization and purification of proteins containing phosphotyrosyl residues. |
