| Product Name | PIN antibody [9S2] |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | Mouse monoclonal antibody [9S2] to PINCytoplasmic dyneins are large enzyme complexes with a molecular mass of about 1,200 kD. They contain two force-producing heads formed primarily from dynein heavy chains, and stalks linking the heads to a basal domain, which contains a varying number of accessory intermediate chains. The complex is involved in intracellular transport and motility. The protein described in this record is a light chain and exists as part of this complex but also physically interacts with and inhibits the activity of neuronal nitric oxide synthase. Binding of this protein destabilizes the neuronal nitric oxide synthase dimer, a conformation necessary for activity, and it may regulate numerous biologic processes through its effects on nitric oxide synthase activity. Alternate transcriptional splice variants have been characterized. [provided by RefSeq, Jul 2008] |
| Immunogen | Human recombinant PIN |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG1 |
| Clone Number | 9S2 |
| Host Species | Mouse |
| Tested Applications | WB |
| WB(1:500-1000) | |
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Synonyms | DNCL1 , dynein, light chain, LC8-type 1 , LC8a , hdlc1 , DLC1 , LC8 , DNCLC1 , DYNLL1 , DLC8 |
|---|---|
| Target | PIN |
| Tissue Specificity | This antibody was selected for its ability to specifically detect human PIN. |
| Application Notes | WB(1:500-1000) |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Keep as concentrated solution. Aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | PBS |
