| Product Name | Plasminogen antibody [SBF1 C1.21] |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | Mouse monoclonal [SBF1 C1.21] to PlasminogenPlasminogen is a plasma protein synthesised mostly in the liver. Plasma concentration is usually in the range of 70 - 200mg/L. Plasminogen is activated by tissue-plasminogen activator, urokinase and streptokinase, to form plasmin. Activation results from the cleavage and release of the preactivation peptide. Angiostatin, an internal fragment of plasminogen, is a potent inhibitor of angiogenesis, which selectively inhibits endothelial cell proliferation. Angiostatin potently inhibits tumor growth and can maintain metastatic and primary tumors in a dormant state. It is defined by a balance of proliferation and apoptosis of the tumor cells and is composed of plasminogen first four cringle structures. This molecule is generated by proteolytic cleavage of plasminogen. |
| Immunogen | Full length protein. Human Plasminogen. |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG1 |
| Clone Number | SBF1 C1.21 |
| Host Species | Mouse |
| Tested Applications | ELISA |
| ELISA: Use at an assay dependent dilution. Optimal dilutions/concentrations should be determined by the end user. | |
| Species Reactivity | Human |
| Concentration | 1mg/ml (Please refer to the vial label for the specific concentration) |
| Purification | Unpurified |
| Gene Synonyms | Microplasmin, Angiostatin, PLG, Plasminogen, DKFZp779M0222 |
|---|---|
| Target | Plasminogen |
| Tissue Specificity | Cross reacts with plasmin, but not with HGF1/MSP or HGF/SF. |
| Cellular Localization | Secreted |
| Application Notes | ELISA: Use at an assay dependent dilution. Optimal dilutions/concentrations should be determined by the end user. |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Keep as concentrated solution. Store at 4ºC short term. For extended storage aliquot and store at -20ºC or below. Avoid freeze-thaw cycles. |
| Storage Buffer | Preservative: None. Constituents: PBS |
