Application
Immunohistochemistry staining of ABCB1 in kidney tissue using ABCB1 Antibody.| Product Name | ABCB1 Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | ABCB1, ABC20, Abcb1b, CLCS, Colchicin sensitivity, CD243, Doxorubicin resistance, IBD13, gp170, MDR1, Multidrug resistance protein 1, P glycoprotein, P-glycoprotein 1, P-GP, CD243 antigen, PGY1 |
| Product description | ATP-Binding Cassette Sub-Family B Member 1 (ABCB1, also named P-glycoprotein) is a plasma membrane-associated multidrug transporter that utilizes the energy of ATP hydrolysis to pump toxic xenobiotics out of cells. Unique features of ABCB1 are its very broad substrate specificity and its basal ATPase activity in the absence of transport substrates. Human ABCB1 plays an important role in absorption, distribution, metabolism, excretion and toxicity of pharmacologically relevant drugs. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anti-cancer drugs. This protein also functions as a transporter across the blood-brain barrier. |
| Immunogen | ABCB1 antibody was raised against amino acids 262 - 277 of ABCB1 (Human). |
| Clonality | Polyclonal |
|---|---|
| Host Species | Rabbit |
| Tested Applications | ELISAIHCWB |
| ABCB1 antibody can be used in Western Blot, and immunohistochemistry starting at 2.5 μg/mL.: |
|
| Species Reactivity | DogHumanMonkeyMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | ABCB1 |
|---|---|
| Alternative Names | ABCB1 ABC20 Abcb1b CLCS Colchicin sensitivity CD243 Doxorubicin resistance IBD13 gp170 MDR1 Multidrug resistance protein 1 P glycoprotein P-glycoprotein 1 P-GP CD243 antigen PGY1 |
Application
Immunohistochemistry staining of ABCB1 in kidney tissue using ABCB1 Antibody.| Application Notes | ABCB1 antibody can be used in Western Blot, and immunohistochemistry starting at 2.5 μg/mL.: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Store ABCB1 antibody at 4 ˚C or -20 ˚C. As with all antibodies avoid freeze/thaw cycles. Store undiluted. |
| Storage Buffer | 0.02 M potassium phosphate, 0.15 M sodium chloride, pH 7.2, 0.01% sodium azide. |
