Application
Presenilin 1 antibody [C1C3] detects Presenilin 1 protein at cell membrane and cytoplasm in rat lung by immunohistochemical analysis. Sample: Paraffin-embedded rat lung. Presenilin 1 antibody [C1C3] diluted at 1:500.Application
Presenilin 1 antibody [C1C3] detects Presenilin 1 protein at cell membrane and cytoplasm in rat adrenal gland by immunohistochemical analysis. Sample: Paraffin-embedded rat adrenal gland. Presenilin 1 antibody [C1C3] diluted at 1:500.Application
Immunohistochemical analysis of paraffin-embedded SW480 xenograft, using Presenilin 1 antibody at 1:100 dilution.Application
Presenilin 1 antibody [C1C3] detects PSEN1 protein at cytosol on U373 xenograft by immunohistochemical analysis. Sample: Paraffin-embedded U373 xenograft. Presenilin 1 antibody [C1C3] dilution: 1:200.Application
Presenilin 1 antibody [C1C3] detects PSEN1 protein at cytosol on mouse brain by immunohistochemical analysis. Sample: Paraffin-embedded mouse brain. Presenilin 1 antibody [C1C3] dilution: 1:200.Application
Sample (30 ug of whole cell lysate) A: Raji 10% SDS PAGE diluted at 1:1000Application
Sample (30 ug of whole cell lysate) A:NIH-3T3 10% SDS PAGE diluted at 1:1000| Product Name | Presenilin 1 antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | Rabbit Polyclonal antibody to Presenilin 1 (presenilin 1)Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1; PSEN2) or in the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor, such that they either directly regulate gamma-secretase activity or themselves are protease enzymes. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene, the full-length nature of only some have been determined. [provided by RefSeq] |
| Immunogen | Recombinant protein encompassing a sequence within the center region of human Presenilin 1. The exact sequence is proprietary. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | IHC-PWB |
| *Optimal dilutions/concentrations should be determined by the researcher.
: |
|
| Species Reactivity | HumanMouseRat |
| Predicted Reactivity | Dog, Pig, Rhesus Monkey, BovineDog (86%), Pig (84%), Rhesus Monkey (100%), Bovine (86%) |
| Concentration | 0.2mg/ml |
| Purification | Affinity purified |
| Gene Synonyms | AD3 antibody FAD antibody PS1 antibody S182 antibody PSEN1 antibody presenilin-1 antibody presenilin 1 antibody |
|---|---|
| Molecular Weight(MW) | 53 kDa (note) (2) |
Application
Presenilin 1 antibody [C1C3] detects Presenilin 1 protein at cell membrane and cytoplasm in rat lung by immunohistochemical analysis. Sample: Paraffin-embedded rat lung. Presenilin 1 antibody [C1C3] diluted at 1:500.
Application
Presenilin 1 antibody [C1C3] detects Presenilin 1 protein at cell membrane and cytoplasm in rat adrenal gland by immunohistochemical analysis. Sample: Paraffin-embedded rat adrenal gland. Presenilin 1 antibody [C1C3] diluted at 1:500.
Application
Immunohistochemical analysis of paraffin-embedded SW480 xenograft, using Presenilin 1 antibody at 1:100 dilution.
Application
Presenilin 1 antibody [C1C3] detects PSEN1 protein at cytosol on U373 xenograft by immunohistochemical analysis. Sample: Paraffin-embedded U373 xenograft. Presenilin 1 antibody [C1C3] dilution: 1:200.
Application
Presenilin 1 antibody [C1C3] detects PSEN1 protein at cytosol on mouse brain by immunohistochemical analysis. Sample: Paraffin-embedded mouse brain. Presenilin 1 antibody [C1C3] dilution: 1:200.
Application
Sample (30 ug of whole cell lysate) A: Raji 10% SDS PAGE diluted at 1:1000
Application
Sample (30 ug of whole cell lysate) A:NIH-3T3 10% SDS PAGE diluted at 1:1000| Positive Control | 293T , A431 , Jurkat , Raji , NIH-3T3 |
|---|---|
| Application Notes | *Optimal dilutions/concentrations should be determined by the researcher.
: |
| Form | Liquid |
|---|---|
| Storage Instructions | Keep as concentrated solution. Aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | 0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative. |
