Application
Western blot analysis of extracts of various cell lines, using PSEN2 antibody.Application
Immunohistochemistry of paraffin-embedded rat heart using PSEN2 antibody at dilution of 1:100 (x400 lens).Application
Immunohistochemistry of paraffin-embedded human kidney using PSEN2 antibody at dilution of 1:100 (x400 lens).| Product Name | Presenilin 2 antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | Rabbit Polyclonal antibody to Presenilin 2Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1 or PSEN2) or the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor such that, they either directly regulate gamma-secretase activity, or themselves act are protease enzymes. Two alternatively spliced transcript variants encoding different isoforms of PSEN2 have been identified. [provided by RefSeq, Jul 2008] |
| Immunogen | A synthetic peptide of human PSEN2 |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | IHCIHC-PWB |
| WB: 1:500 - 1:2000, IHC: 1:50 - 1:200: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Synonyms | CMD1V presenilin 2 AD4 AD3L STM2 PS2 PSEN2 |
|---|---|
| Target | Presenilin 2 |
Application
Western blot analysis of extracts of various cell lines, using PSEN2 antibody.
Application
Immunohistochemistry of paraffin-embedded rat heart using PSEN2 antibody at dilution of 1:100 (x400 lens).
Application
Immunohistochemistry of paraffin-embedded human kidney using PSEN2 antibody at dilution of 1:100 (x400 lens).| Application Notes | WB: 1:500 - 1:2000, IHC: 1:50 - 1:200: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
