Application
Application| Product Name | Presenilin 2 antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | Mouse monoclonal [198C679.2.1] to Presenilin 2Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1; PSEN2) or the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor, such that that they either directly regulate gamma-secretase activity or themselves are protease enzymes. Two alternative transcripts of PSEN2 have been identified. |
| Immunogen | Synthetic peptide (Human). |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgM |
| Clone Number | 198C679.2.1 |
| Host Species | Mouse |
| Tested Applications | WB |
| WB: Use at a dilution of 1/250 - 1/500. Detects a band of approximately 55 kDa (predicted molecular weight: 54 kDa). It tested negative in mouse NIH 3T3 cells. Optimal dilutions/concentrations should be determined by the end user.: |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | Presenilin 2 Presenilin2 AD3L AD4 CMD1V PS2 STM2 |
|---|---|
| Target | Presenilin 2 |
| Cellular Localization | Cell Membrane, Endoplasmic reticulum and Golgi Apparatus |
Application
Application| Positive Control | HL-60 or Jurkat cells |
|---|---|
| Application Notes | WB: Use at a dilution of 1/250 - 1/500. Detects a band of approximately 55 kDa (predicted molecular weight: 54 kDa). It tested negative in mouse NIH 3T3 cells. Optimal dilutions/concentrations should be determined by the end user.: |
| Form | Liquid |
|---|---|
| Storage Instructions | Keep as concentrated solution. Store at 4ºC short term. For extended storage aliquot and store at -20ºC or below. Avoid freeze-thaw cycles. |
| Storage Buffer | Preservative: 0.02% Sodium Azide |
