| Product Name | Procalcitonin antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | Mouse monoclonal [38F11] to ProcalcitoninProcalcitonin (PCT) is a 116 amino acid residue peptide with molecular weight of about 13 kDa. The amino acid sequence of PCT was firstly described by Moullec et al. in 1984. It belongs to a group of related proteins including calcitonin gene-related peptides I and II, amylin, adrenomodulin and calcitonin (CAPA peptide family). PCT, like other peptides of CAPA family, appears from the common precursor pre-procalcitonin consisting of 141 amino acids by removal of 25 a.a.r. from N-terminus. PCT is produced normally in C-cells of the thyroid glands. It undergoes successive cleavages to form three molecules: N-terminal fragment (55 a.a.r.), calcitonin (32 a.a.r.) and katacalcin (21 a.a.r.). It has been shown that the level of PCT in serum increases significantly during an infection of bacterial origin (Assicot M, et al). Today PCT is considered to be one of the earliest and most specific markers of sepsis. However, several studies revealed that elevated PCT level in human blood could be detected not only in case of sepsis and infection, but also in cases of surgery, polytrauma, heat shock and cardiogenic shock (Meisner M. & Reinhart K). The importance of PCT measurements in combination with cTnT or cTnI during heart transplantation to predict an early graft failure has been proved(Potapov EV., et al). |
| Immunogen | Recombinant fragment (Human). |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG1 |
| Clone Number | 38F11 |
| Host Species | Mouse |
| Tested Applications | ELISAWB |
| ELISA: Use at an assay dependent dilution. WB: Use at an assay dependent dilution. Pair for sandwich ELISA: GTX11498 for capture antibody, and GTX11491 Catacalcin antibody [22A11] for detection antibody. Optimal dilutions should be determined experimentally by the end user.: |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Purification | Protein A |
| Gene Synonyms | CALC1 CGRP CGRP-I CGRP1 CT KC MGC126648 CGRP I CGRPI |
|---|---|
| Target | Procalcitonin |
| Application Notes | ELISA: Use at an assay dependent dilution. WB: Use at an assay dependent dilution. Pair for sandwich ELISA: GTX11498 for capture antibody, and GTX11491 Catacalcin antibody [22A11] for detection antibody. Optimal dilutions should be determined experimentally by the end user.: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Keep as concentrated solution, aliquot and store at 4°C. |
| Storage Buffer | Preservative: 0.1% Sodium Azide; Constituents: PBS. pH 7.4 |
