Application
Western blot analysis of AGTR2 in mouse liver tissue lysate with AGTR2 antibody at 0.5 μg/mL.Application
Immunohistochemistry of AGTR2 in rat liver tissue with AGTR2 antibody at 5 μg/mL.| Product Name | AGTR2 Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | AGTR2 Antibody: AT2, ATGR2, MRX88, Type-2 angiotensin II receptor, Angiotensin II type-2 receptor, AT2 |
| Product description | AGTR2 Antibody: Angiotensin II is a potent vasopressor hormone and a primary regulator of aldosterone secretion that acts through at least two types of receptors, AGTR1 and AGTR2. It is an important effector controlling blood pressure and volume in the cardiovascular system and plays a major role in the development of the mammalian kidney and urinary tract. Like AGTR1, AGTR2 is a seven transmembrane G protein-coupled receptor (GPCR), but AGTR2 does not demonstrate most of the classic features of GPCR signaling. AGTR2 is involved in a wide range of activities, including the induction of neurite outgrowth and the inhibition of cellular proliferation, in addition to the known function of mediation of vasoconstriction.1) Mottl AK, Shoham DA, and North KE. Angiotensin II type 1 receptor polymorphisms and susceptibility to hypertension: A HuGE review. Gen. in Med. 2008; 10:560-574. |
| Immunogen | AGTR2 antibody was raised against a 16 amino acid synthetic peptide from near the center of human AGTR2. The immunogen is located within amino acids 220 - 270 of AGTR2. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | ELISAIHC-PWB |
| AGTR2 antibody can be used for detection of AGTR2 by Western blot at 0.5 μg/mL. Antibody can also be used for immunohistochemistry starting at 5 μg/mL.: |
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| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | AGTR2 |
|---|---|
| Alternative Names | AGTR2 Antibody: AT2 ATGR2 MRX88 Type-2 angiotensin II receptor Angiotensin II type-2 receptor AT2 |
| Molecular Weight(MW) | Predicted: 40 kDa Observed: 36 kDa |
| Sequence Similarities | Predicted species reactivity based on immunogen sequence: Sheep: (100%) |
Application
Western blot analysis of AGTR2 in mouse liver tissue lysate with AGTR2 antibody at 0.5 μg/mL.
Application
Immunohistochemistry of AGTR2 in rat liver tissue with AGTR2 antibody at 5 μg/mL.| Positive Control | 1) Cat. No. 1404 - Mouse Liver Tissue Lysate |
|---|---|
| Application Notes | AGTR2 antibody can be used for detection of AGTR2 by Western blot at 0.5 μg/mL. Antibody can also be used for immunohistochemistry starting at 5 μg/mL.: |
| Form | Liquid |
|---|---|
| Storage Instructions | AGTR2 antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. |
| Storage Buffer | AGTR2 Antibody is supplied in PBS containing 0.02% sodium azide. |
