APBA1 is a member of the X11 protein family. It is a neuronal adaptor protein that interacts with the Alzheimer's disease amyloid precursor protein (APP). It stabilises APP and inhibits production of proteolytic APP fragments including the A beta peptide that is deposited in the brains of Alzheimer's disease patients. APBA1 is believed to be involved in signal transduction processes. It is also regarded as a putative vesicular trafficking protein in the brain that can form a complex with the potential to couple synaptic vesicle exocytosis to neuronal cell adhesion.
Immunogen
Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human APBA1.
Key Feature
Clonality
Polyclonal
Host Species
Rabbit
Tested Applications
ELISAIHCWB
APBA1 antibody can be used for detection of APBA1 by ELISA at 1:62500. APBA1 antibody can be used for detection of APBA1 by western blot at 0.25 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.:
Antibody used in IHC on Rat hippocampal at: 1:200.
Application
Antibody used in WB on Human Raji at 0.2-1 ug/ml.
Application
Antibody used in IHC on Human Intestine.
Positive Control
1) Cat. No. 1207 - Raji Cell Lysate
Application Notes
APBA1 antibody can be used for detection of APBA1 by ELISA at 1:62500. APBA1 antibody can be used for detection of APBA1 by western blot at 0.25 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.:
Additional Information
Form
Liquid
Storage Instructions
For short periods of storage (days) store at 4˚C. For longer periods of storage, store APBA1 antibody at -20˚C. As with any antibody avoid repeat freeze-thaw cycles.
Storage Buffer
Antibody is lyophilized in PBS buffer with 2% sucrose. Add 50 μL of distilled water. Final antibody concentration is 1 mg/mL.