Application
Western blot analysis of PRTFDC1 in human brain tissue lysate with PRTFDC1 antibody at 1 ug/ml in the (A) absence and (B) presence of blocking peptide.| Product Name | PRTFDC1 antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | Rabbit polyclonal antibody to PRTFDC1Phosphoribosyl transferase domain containing 1 (PRTFDC1) is highly homologous to the hypoxanthine phosphoribosyltransferase (HPRT1) and may have arisen from a gene duplication event of a common ancestor gene. Recently, it was shown that CpG islands in the PRTFDC1 promoter could be hypermethylated in ovarian cancers and oral squamous-cell carcinomas (OSCC), leading to gene silencing. Restoration of PRTFDC1 expression in OSCC inhibited cell growth in colony-formation assays, while knockdown of PRTFDC1 expression in OSCC that expressed the gene promoted cell growth. These results suggest that PRTFDC1 can act as a tumor-suppressor gene. At least three isoforms of PRTFDC1 are known to exist. |
| Clonality | Polyclonal |
|---|---|
| Host Species | Rabbit |
| Tested Applications | ELISAWB |
| WB:1:500~1:2000 Notes:Optimal dilutions/concentrations should be determined by the researcher. |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Synonyms | PRTFDC1 HHGP Phosphoribosyl transferase domain containing1 Phosphoribosyl transferase domain containing 1 |
|---|---|
| Target | PRTFDC1 |
| Tissue Specificity | This antibody is specific for PRTFDC1 |
Application
Western blot analysis of PRTFDC1 in human brain tissue lysate with PRTFDC1 antibody at 1 ug/ml in the (A) absence and (B) presence of blocking peptide.| Positive Control | Blocking Peptide: Cat.No. GTX85380-PEP - PRTFDC1 Peptide Lysates: Cat. No. GTX27918 - Human Brain Tissue Lysate |
|---|---|
| Application Notes | WB:1:500~1:2000 Notes:Optimal dilutions/concentrations should be determined by the researcher. |
| Form | Liquid |
|---|---|
| Storage Instructions | Keep as concentrated solution. Aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | PBS containing 0.02% sodium azide |
