Ankyrin repeat and SOCS box protein 2, ASB-2, ASB2
Product description
The protein encoded by this gene is a member of the
ankyrin repeat and SOCS box-containing (ASB) family of proteins.
They contain ankyrin repeat sequence and SOCS box domain. The SOCS
box serves to couple suppressor of cytokine signalling (SOCS)
proteins and their binding partners with the elongin B and C
complex, possibly targeting them for degradation. This gene is
induced by all-trans retinoic acid. In myeloid leukemia cells, the
expression of this encoded protein has been shown to induce growth
inhibition and chromatin condensation. Multiple alternatively
spliced transcript variants have been described for this gene but
their full length sequences are not known.1) Heuze, M.L., et al. Blood 112(13):5130-5140(2008)
Immunogen
This ASB2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 58-86 amino acids from the N-terminal region of human ASB2.
Western blot analysis in U937 cell line lysates (35ug/lane).
Application
Western Blot at 1:1000 dilution + human lung lysate Lysates/proteins at 20 ug per lane.
Application Notes
For WB starting dilution is: 1:1000:
Additional Information
Form
Liquid
Storage Instructions
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.