Rabbit Polyclonal antibody to PTGDSThe protein encoded by this gene is a glutathione-independent prostaglandin D synthase that catalyzes the conversion of prostaglandin H2 (PGH2) to postaglandin D2 (PGD2). PGD2 functions as a neuromodulator as well as a trophic factor in the central nervous system. PGD2 is also involved in smooth muscle contraction/relaxation and is a potent inhibitor of platelet aggregation. This gene is preferentially expressed in brain. Studies with transgenic mice overexpressing this gene suggest that this gene may be also involved in the regulation of non-rapid eye movement sleep. [provided by RefSeq, Jul 2008]
Immunogen
Recombinant protein of human PTGDS
Key Feature
Clonality
Polyclonal
Isotype
IgG
Host Species
Rabbit
Tested Applications
IHCIHC-PWB
WB: 1:500 - 1:2000, IHC: 1:50 - 1:200:
Species Reactivity
HumanMouseRat
Concentration
1mg/ml
Purification
Affinity purified
Target Information
Gene Synonyms
LPGDS PGDS2 PDS PGDS L PGDS PGD2 prostaglandin D2 synthase
Target
PTGDS
Application
Application
Western blot analysis of extracts of mouse heart, using PTGDS antibody.
Application
Immunohistochemistry of paraffin-embedded rat brain using PTGDS antibody at dilution of 1:200 (40x lens).