Application
Immunohistochemistry staining of CBLC in pancreas tissue using CBLC Antibody.| Product Name | CBLC Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | CBLC, CBL-3, CBL3, RNF57, SH3-binding protein CBL-C, SH3-binding protein CBL-3, CBL-c, CBL-SL, RING finger protein 57 |
| Product description | Cbl-c is also known as signal transduction protein CBL-C, SH3-binding protein CBL-C, CBL-3, and RING finger protein 57. Cbl proteins are a family of ubiquitin protein ligases (E3s) that negatively regulate signaling by targeting activated tyrosine kinases for degradation. Cbl-c (a.k.a. Cbl-3) is the most recently cloned member of the Cbl proteins and is expressed only in epithelial cells (the other Cbl proteins are ubiquitously expressed). Cbl-c, like the other mammalian Cbl proteins, can ubiquitinate the activated EGFR and target it for degradation. Cbl-c knock out mice show no obvious phenotype. Thus, the physiological role of Cbl-c is not known. |
| Immunogen | CBLC antibody was raised against amino acids 444 - 458 of CBLC (Human). |
| Clonality | Polyclonal |
|---|---|
| Host Species | Rabbit |
| Tested Applications | ELISAIFIHCIPWB |
| CBLC antibody can be used in Western Blot, and immunohistochemistry starting at 10 μg/mL.: |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | CBLC |
|---|---|
| Alternative Names | CBLC CBL-3 CBL3 RNF57 SH3-binding protein CBL-C SH3-binding protein CBL-3 CBL-c CBL-SL RING finger protein 57 |
Application
Immunohistochemistry staining of CBLC in pancreas tissue using CBLC Antibody.| Application Notes | CBLC antibody can be used in Western Blot, and immunohistochemistry starting at 10 μg/mL.: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Store CBLC antibody at 4 ˚C or -20 ˚C. As with all antibodies avoid freeze/thaw cycles. |
| Storage Buffer | 0.02 M potassium phosphate, 0.15 M sodium chloride, pH 7.2, 0.01% sodium azide. |
