This gene encodes a member of the Cbl family of E3 ubiquitin ligases. Cbl proteins play important roles in cell signaling through the ubiquitination and subsequent downregulation of tyrosine kinases. Expression of this gene may be restricted to epithelial cells, and alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2012]
Alternative Names
CBL-3 RNF57 CBL-SL
Molecular Weight(MW)
~ 52 kDa
Application
WB
Western blot analysis of extracts of various cells, using CBLC antibody.
ICC/IF
Immunofluorescence analysis of A549 cell using CBLC antibody.
Application Notes
WB:1:500 - 1:2000 ICC/IF:1:50 - 1:100
Additional Information
Form
Liquid
Storage Instructions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Storage Buffer
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2