Thermolysin-like specificity, but is almost confined on acting on polypeptides of up to 30 amino acids. Biologically important in the destruction of opioid peptides such as Met- and Leu-enkephalins by cleavage of a Gly-Phe bond. Able to cleave angiotensin-1, angiotensin-2 and angiotensin 1-9. Involved in the degradation of atrial natriuretic factor (ANF). Displays UV-inducible elastase activity toward skin preelastic and elastic fibers.1) Yandle T. G., Brennan S. O., Espiner E. A., Nicholls M. G., Richards A. M. Peptides 10:891-894 (1989) Rice G. I., Thomas D. A., Grant P. J., Turner A. J., Hooper N. M. Biochem. J. 383:45-51 (2004) Morisaki N., Moriwaki S., Sugiyama-Nakagiri Y., Haketa K., Takema Y., Imokawa G. J. Biol. Chem. 285:39819-39827 (2010)
Immunogen
CD10 antibody was raised against a peptide sequence around aa.6~10 (S-Q-M-D-I) derived from Human CD10.