| Product Name | CD54 Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | BB2, CD54, P3.58, ICAM1 |
| Product description | The 15.2 antibody reacts with the 85-110 kDa intracellular adhesion molecule-1 (ICAM-1), a member of the Ig superfamily which acts as a ligand for the Lymphocyte Function-Associated Antigen-1 (LFA-1). ICAM-1 is also known CD 54 and is expressed on non-hematopoietic cells of vascular endothelial, thymic epithelial, fibroblasts lineages, and on hematopoietic cells like macrophages, mitogen-stimulated T-lymphoblasts, dendritic cells in tonsils, lymph nodes and Peyer’s patches, and germinal center B cells.Inflammatory mediators (IL-1, TNF, IFN-gamma) enhance the production of ICAM-1 on fibroblasts and endothelial cells within few hours. Thus, ICAM-1 seems to be the marker of inflammatory reactions.1) Bhattacharya, A. L. O. K., Dorf, M. E., Springer, T. A. (1981). A shared alloantigenic determinant on Ia antigens encoded by the IA and IE subregions: evidence for I region gene duplication. The Journal of Immunology,127(6), 2488-2495. |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG1 |
| Host Species | Mouse |
| Tested Applications | FACSFunctionalStudiesIHCWB |
| FACS:1:200~1:500 IHC:1:50~1:200 WB:1:500~1:2000 Notes:Optimal dilutions/concentrations should be determined by the researcher. |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | ICAM1 |
|---|---|
| Alternative Names | BB2 CD54 P3.58 ICAM1 |
| Tissue Specificity | The 15.2 antibody reacts with the 85-110 kDa intracellular adhesion molecule-1 (ICAM-1), a member of the Ig superfamily which acts as a ligand for the Lymphocyte Function-Associated Antigen-1 (LFA-1). |
| Entrez Gene | 3383 |
|---|
| Application Notes | FACS:1:200~1:500 IHC:1:50~1:200 WB:1:500~1:2000 Notes:Optimal dilutions/concentrations should be determined by the researcher. |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | The product should be stored undiluted at 4˚C . Do not freeze. |
| Storage Buffer | Phosphate-buffered aqueous solution, ph7.2. |
