Application
Immunofluorescence of Clusterin in mouse brain tissue with Clusterin Antibodyat 20 μg/mL.Application
Immunohistochemistry of Clusterin in human brain tissue with Clusterin antibody at 5 μg/mL.Application
Immunohistochemistry of Clusterin in mouse brain tissue with Clusterin Antibodyat 5 μg/mL.Application
Immunofluorescence of Clusterin in human brain tissue with Clusterin antibody at 20 μg/ml.Application
Immunohistochemistry of Clusterin in human brain tissue with Clusterin antibody at 10 μg/mL.Application
Western blot analysis of Clusterin in human brain tissue lysate with Clusterin body at (A) 0.5 and (B) 1 μg/mL.| Product Name | Clusterin Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | Clusterin Antibody: CLI, AAG4, APOJ, CLU1, CLU2, KUB1, SGP2, APO-J, SGP-2, SP-40, TRPM2, TRPM-2, NA1/NA2, CLI, Clusterin, Aging-associated gene 4 protein, Apo-J |
| Product description | Clusterin Antibody: Clusterin, also known as Apolipoprotein J (ApoJ), is a ubiquitous multifunctional glycoprotein that can interact with a broad spectrum of molecules such as complement components, various receptors, and the Alzheimer's b-amyloid peptide. Clusterin expression is increased in Alzheimer's disease brain tissue and clusterin-immunoreactive amyloid plaques are found associated with phospho-tau-positive dystrophic neurites and it has been suggested that clusterin facilitates the conversion of diffuse b-amyloid deposits into amyloid and enhances tau phosphorylation in neurites around these plaques. Other reports show that clusterin expression is decreased in proliferating cells and is upregulated in quiescent and senescent cells, suggesting that it may also play a role in aging and tumorigenesis suppression. Clusterin exists in at least two distinct isoforms.1) Calero M, Rostagno A, Frangione B, et al. Clusterin and Alzheimer’s disease. Subcell. Biochem. 2005; 38:273-98. |
| Immunogen | Clusterin antibody was raised recombinant human Clusterin isoform 1. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | ELISAIFIHC-PWB |
| Clusterin antibody can be used for the detection of Clusterin by Western blot at 0.5 - 1 μg/mL. Antibody can also be used for immunohistochemistry starting at 5 μg/mL. For immunofluorescence start at 20 μg/mL.: |
|
| Species Reactivity | HumanMouse |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | CLU |
|---|---|
| Alternative Names | Clusterin Antibody: CLI AAG4 APOJ CLU1 CLU2 KUB1 SGP2 APO-J SGP-2 SP-40 TRPM2 TRPM-2 NA1/NA2 CLI Clusterin Aging-associated gene 4 protein Apo-J |
| Sequence Similarities | 2) Cat. No. 10-301 - Human Brain Tissue Slide |
Application
Immunofluorescence of Clusterin in mouse brain tissue with Clusterin Antibodyat 20 μg/mL.
Application
Immunohistochemistry of Clusterin in human brain tissue with Clusterin antibody at 5 μg/mL.
Application
Immunohistochemistry of Clusterin in mouse brain tissue with Clusterin Antibodyat 5 μg/mL.
Application
Immunofluorescence of Clusterin in human brain tissue with Clusterin antibody at 20 μg/ml.
Application
Immunohistochemistry of Clusterin in human brain tissue with Clusterin antibody at 10 μg/mL.
Application
Western blot analysis of Clusterin in human brain tissue lysate with Clusterin body at (A) 0.5 and (B) 1 μg/mL.| Positive Control | 1) Cat. No. 1303 - Human Brain Tissue Lysate |
|---|---|
| Application Notes | Clusterin antibody can be used for the detection of Clusterin by Western blot at 0.5 - 1 μg/mL. Antibody can also be used for immunohistochemistry starting at 5 μg/mL. For immunofluorescence start at 20 μg/mL.: |
| Form | Liquid |
|---|---|
| Storage Instructions | Clusterin antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. |
| Storage Buffer | Clusterin Antibody is supplied in PBS containing 0.02% sodium azide. |
