Application
Immunohistochemistry staining of CRTC1 in kidney tissue using CRTC1 Antibody.| Product Name | CRTC1 Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | MECT1 (also known as MucoEpidermoid Carcinoma Translocated 1, Transducer of regulated cAMP response element-binding protein 1, TORC1, and Transducer of CREB protein 1) is a nuclear protein that functions as a transcriptional coactivator for CREB1, which activates transcription through both consensus and variant cAMP response element (CRE) sites. MECT1does not appear to modulate CREB1 DNA-binding activity but enhances the interaction of CREB1 with TAF4/TAFII-130. MECT1 translocates with MAML2 (MasterMind-Like Protein 2) to yield a fusion oncogene: t(11;19) (q21;p13). This translocation occurs in mucoepidermoid carcinomas, benign Warthin tumors and clear cell hidradenomas. The novel fusion product that results disrupts the Notch signaling pathway. The fusion protein consists of the N-terminus of MECT1 joined to the C-terminus of MAML2. The reciprocal fusion protein consisting of the N-terminus of MAML2 joined to the C-terminus of MECT1 has been detected in a small number of mucoepidermoid carcinomas. Multiple isoforms have been reported for the MECT1 protein. |
| Immunogen | CRTC1 antibody was raised against amino acids 19 - 34 of CRTC1 (Human). |
| Clonality | Polyclonal |
|---|---|
| Host Species | Rabbit |
| Tested Applications | ELISAIFIHCWB |
| CRTC1 antibody can be used in ELISA starting at 1:14000 - 1:80000, Western Blot starting at 1:100 - 1:8000, immunohistochemistry starting at 5 μg/mL, and immunofluorescence. | |
| Species Reactivity | BovineHumanMousePuffer Fish(Fugu)RatZebra Fish |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | CRTC1 |
|---|---|
| Alternative Names | CRTC1 KIAA0616 MECT1 TORC-1 TORC1 Transducer of CREB protein 1 WAMTP1 |
Application
Immunohistochemistry staining of CRTC1 in kidney tissue using CRTC1 Antibody.| Application Notes | CRTC1 antibody can be used in ELISA starting at 1:14000 - 1:80000, Western Blot starting at 1:100 - 1:8000, immunohistochemistry starting at 5 μg/mL, and immunofluorescence. |
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| Form | Liquid |
|---|---|
| Storage Instructions | Store CRTC1 antibody at 4 ˚C or -20 ˚C. As with all antibodies avoid freeze/thaw cycles. |
| Storage Buffer | 0.02 M potassium phosphate, 0.15 M sodium chloride, pH 7.2, 0.01% sodium azide. |
