Binds and transactivates the sequence 5'-TAATC[CA]-3' which is found upstream of several photoreceptor-specific genes, including the opsin genes. Acts synergistically with other transcription factors, e.g. NRL and RX, to regulate photoreceptor cell-specific gene transcription. Essential for the maintenance of mammalian photoreceptors.1) Freund C.L.,et al.Cell 91:543-553(1997).
Immunogen
This CRX antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 294-297 amino acids from the C-terminal region of human CRX.
Western blot analysis of lysate from Y79 cell line, using CRX Antibody at 1:1000.
Application Notes
For WB starting dilution is: 1:1000
Additional Information
Form
Liquid
Storage Instructions
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.