Down-regulates ESR1 protein levels through the ubiquitination-proteasome pathway, regardless of the presence of 17 beta-estradiol. Also involved in 17 beta-estradiol-induced ESR1 degradation. Controls PGR protein levels through a similar mechanism.1) Zhang P. -J., Zhao J., Li H. -Y., Man J. -H., He K., Zhou T., Pan X., Li A. -L., Gong W. -L., Jin B. -F., Xia Q., Yu M., Shen B. -F., Zhang X. -M. EMBO J. 26:1831-1842 (2007)
Immunogen
CUEDC2 antibody was raised against a peptide sequence around aa.262~266 (D-V-R-N-P) derived from Human CUEDC2.