Application
Western blot analysis in K562 cell line lysates (35ug/lane).| Product Name | GCHFR Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | GTP cyclohydrolase I feedback regulatory protein binds to and mediates tetrahydrobiopterin inhibition of GTP cyclohydrolase I. The regulatory protein, GCHFR, consists of a homodimer. It is postulated that GCHFR may play a role in regulating phenylalanine metabolism in the liver and in the production of biogenic amine neurotransmitters and nitric oxide.1) Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010) McHugh, P.C., et al. Pharmacogenomics J. (2010) In pressLi, L., et al. Circ. Res. 106(2):328-336(2010) Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009) Schnetz-Boutaud, N.C., et al. Genes Brain Behav. 8(8):753-757(2009) |
| Immunogen | This GCHFR antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 38-66 amino acids from the C-terminal region of human GCHFR. |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WB |
| For WB starting dilution is: 1:1000 | |
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | GCHFR |
|---|---|
| Alternative Names | GTP cyclohydrolase 1 feedback regulatory protein GFRP GTP cyclohydrolase I feedback regulatory protein p35 GCHFR GFRP |
| Molecular Weight(MW) | 10 kDa |
| Sequence Similarities | Predicted species reactivity based on immunogen sequence: Bovine |
Application
Western blot analysis in K562 cell line lysates (35ug/lane).| Application Notes | For WB starting dilution is: 1:1000 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. |
| Storage Buffer | Supplied in PBS with 0.09% (W/V) sodium azide. |
