| Product Name | Girdin Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | Girdin Antibody: APE, GIV, GRDN, HkRP1, GIRDIN, KIAA1212, APE, Girdin, Akt phosphorylation enhancer |
| Product description | Girdin Antibody: Girdin is a Galpha-interacting protein that can enhance the activation of the protein kinase Akt, remodel the actin cytoskeleton, and is thought to be involved in the regulation of cell migration and cancer metastasis. It has recently been shown that Girdin interacts with Disrupted-in-Schizophrenia 1 (DISC1), a susceptibility gene for major psychiatric disorders. DISC1 is thought to be involved in the migration, positioning and differentiation of dentate granule cells (DGCs) during development; depletion of Girdin or blocking the Girdin-DISC1 interaction results in defects in axonal sprouting in the CA3 region of the hippocampus and overextended migration of mispositioning of DGCs, suggesting the Girdin plays a role in postnatal neurogenesis in the dentate gyrus.1) Le-Niculescu H, Niesman I, Fischer T, et al. Identification and characterization of GIV, a novel Galpha i/s-interacting protein found on COPI, endoplasmic reticulum-Golgi transport vesicles. J. Biol. Chem.2005; 280:22012-20. |
| Immunogen | Girdin antibody was raised against a 16 amino acid synthetic peptide from near the carboxy terminus human Girdin. The immunogen is located within the last 50 amino acids of Girdin. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | ELISAIFWB |
| Girdin antibody can be used for detection of Girdin by Western blot at 1 - 2 μg/mL. For immunofluorescence start at 20 μg/mL.: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | CCDC88A |
|---|---|
| Alternative Names | Girdin Antibody: APE GIV GRDN HkRP1 GIRDIN KIAA1212 APE Girdin Akt phosphorylation enhancer |
| Sequence Similarities | 2) Cat. No. 10-301 - Human Brain Tissue Slide |
| Positive Control | 1) Cat. No. 1463 - Rat Brain Tissue Lysate |
|---|---|
| Application Notes | Girdin antibody can be used for detection of Girdin by Western blot at 1 - 2 μg/mL. For immunofluorescence start at 20 μg/mL.: |
| Form | Liquid |
|---|---|
| Storage Instructions | Girdin antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. |
| Storage Buffer | Girdin Antibody is supplied in PBS containing 0.02% sodium azide. |
