Application
Immunohistochemistry staining of HAVCR1 in testis tissue using HAVCR1 Antibody.| Product Name | HAVCR1 Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | HAVCR1, HAVCR-1, KIM-1, Kidney injury molecule 1, KIM1, T-cell membrane protein 1, TIM1, TIMD1, TIM-1, HAVCR, TIMD-1 |
| Product description | HAVCR1, a 359 A.A Class 1 integral membrane glycoprotein, is used by Hepatitis A virus to infect humans. It consists of a conserved N-terminal Cys-rich region, IgV (Immunoglobulin Variable region like) domain and a TSP-rich mucin domain in the extracellular region followed by a highly conserved tyrosine kinase phosphorylation motif in the cytoplasmic region. HAVCR1 is expressed on terminally differentiated CD4+ Th2 cells and regulates cytokine production. It plays an important role in the regulation of immune responses in the development of asthma and allergic responses. Its expression is critically upregulated in dedifferentiated kidney cells, thus indicating a possible role in regeneration of proximal tubule epithelium in Kidneys. HAVCR1 has shown to be upregulated in renal carcinomas, suggesting its role in tumor progression and metastasis. |
| Immunogen | HAVCR1 antibody was raised against amino acids 200 - 300 of HAVCR1 (Human). |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WB |
| HAVCR1 antibody can be used in immunohistochemistry starting at 5 μg/mL.: |
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| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Purification | Protein G |
| Gene Symbol | HAVCR1 |
|---|---|
| Alternative Names | HAVCR1 HAVCR-1 KIM-1 Kidney injury molecule 1 KIM1 T-cell membrane protein 1 TIM1 TIMD1 TIM-1 HAVCR TIMD-1 |
| Tissue Specificity | The amino acid sequence (SPLYSYTTDGNDTVT) used as immunogen for this is 100% homologous in human, 93% homologous in vervet/green monkey and 80% homologous in chimp. Isoforms of different molecular weights have been described for TIM-1. The sequence u ... |
Application
Immunohistochemistry staining of HAVCR1 in testis tissue using HAVCR1 Antibody.| Application Notes | HAVCR1 antibody can be used in immunohistochemistry starting at 5 μg/mL.: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Store HAVCR1 antibody at 4 ˚C for short term applications. For long term storage, aliquot and -20 ˚C. |
| Storage Buffer | PBS, 0.05% BSA, 0.05% sodium azide. |
