Application
Western blot analysis of TIM-1 in 3T3 cell lysate with TIM-1 antibody at 1 μg/mL.Application
Immunofluorescence of TIM-1 in Human Uterus cells with TIM-1 antibody at 20 μg/mL.Application
Immunohistochemistry of TIM-1 in human uterus tissue with TIM-1 antibody at 10 μg/mL.| Product Name | TIM-1 Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | TIM-1 Antibody: TIM, KIM1, TIM1, HAVCR, KIM-1, TIM-1, TIMD1, TIMD-1, HAVCR-1, Hepatitis A virus cellular receptor 1, Kidney injury molecule 1, HAVcr-1 |
| Product description | TIM-1 Antibody: The human form of TIM-1 was initially discovered as a membrane glycoprotein through which the hepatitis A virus can gain entry into a cell. It was also identified as kidney injury molecule 1 (Kim-1), a predicted adhesion molecule that is upregulated on the surfaces of kidney epithelia. It is also expressed on T helper 2 (Th2) cells of the immune system, and following the binding of its natural ligand TIM-4, stimulates T cell expansion and cytokine production in response to viral challenge. It has been suggested that hyperactivation of TIM-1 leads to an increased level of Th2 responsiveness and asthma susceptibility, and antibodies to TIM-1 may therefore be a novel approach to treating asthma.1) Feigelstock D, Thompson P, Mattoo P, et al. The human homolog of HAVcr-1 codes for a hepatitis A virus cellular receptor. J. Virol. 1998; 72:6621-8. |
| Immunogen | TIM-1 antibody was raised against a 16 amino acid synthetic peptide from near the amino terminus of human TIM-1. The immunogen is located within amino acids 50 - 100 of TIM-1. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | ELISAIFIHC-PWB |
| TIM-1 antibody can be used for the detection of TIM-1 by Western blot at 1 μg/mL. Antibody can also be used for immunohistochemistry starting at 10 μg/mL. For immunofluorescence start at 20 μg/mL.: |
|
| Species Reactivity | HumanMouse |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | HAVCR1 |
|---|---|
| Alternative Names | TIM-1 Antibody: TIM KIM1 TIM1 HAVCR KIM-1 TIM-1 TIMD1 TIMD-1 HAVCR-1 Hepatitis A virus cellular receptor 1 Kidney injury molecule 1 HAVcr-1 |
| Molecular Weight(MW) | Predicted: 40 kDa Observed: 44 kDa |
| Sequence Similarities | 3) Cat. No. 11-401 - Human Uterus Tissue Slide |
Application
Western blot analysis of TIM-1 in 3T3 cell lysate with TIM-1 antibody at 1 μg/mL.
Application
Immunofluorescence of TIM-1 in Human Uterus cells with TIM-1 antibody at 20 μg/mL.
Application
Immunohistochemistry of TIM-1 in human uterus tissue with TIM-1 antibody at 10 μg/mL.| Positive Control | 1) Cat. No. 1282 - 3T3 (NIH) Cell Lysate |
|---|---|
| Application Notes | TIM-1 antibody can be used for the detection of TIM-1 by Western blot at 1 μg/mL. Antibody can also be used for immunohistochemistry starting at 10 μg/mL. For immunofluorescence start at 20 μg/mL.: |
| Form | Liquid |
|---|---|
| Storage Instructions | TIM-1 antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. |
| Storage Buffer | TIM-1 Antibody is supplied in PBS containing 0.02% sodium azide. |
