Application
Antibody used in WB on Human Fetal liver at 1 ug/ml.Application
Antibody used in IHC on Human Liver at 5.0 ug/ml.| Product Name | HSD11B1 Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | HSD11B1, 11-DH, 11-beta-HSD1, HDL, HSD11, HSD11B, HSD11L, MGC13539, CORTRD2, SDR26C1 |
| Product description | HSD11B1 is a microsomal enzyme that catalyzes the conversion of the stress hormone cortisol to the inactive metabolite cortisone. In addition, HSD11B1 can catalyze the reverse reaction, the conversion of cortisone to cortisol. Too much cortisol can lead to central obesity, and a particular variation in this gene has been associated with obesity and insulin resistance in children.The protein encoded by this gene is a microsomal enzyme that catalyzes the conversion of the stress hormone cortisol to the inactive metabolite cortisone. In addition, the encoded protein can catalyze the reverse reaction, the conversion of cortisone to cortisol. Too much cortisol can lead to central obesity, and a particular variation in this gene has been associated with obesity and insulin resistance in children. Two transcript variants encoding the same protein have been found for this gene.1) Paulsen, S.K., (2008) Obesity (Silver Spring) 16 (4), 731-735. |
| Immunogen | Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human HSD11B1. |
| Clonality | Polyclonal |
|---|---|
| Host Species | Rabbit |
| Tested Applications | ELISAWB |
| HSD11B1 antibody can be used for detection of HSD11B1 by ELISA at 1:312500. HSD11B1 antibody can be used for detection of HSD11B1 by western blot at 1 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | HSD11B1 |
|---|---|
| Alternative Names | HSD11B1 11-DH 11-beta-HSD1 HDL HSD11 HSD11B HSD11L MGC13539 CORTRD2 SDR26C1 |
| Molecular Weight(MW) | 32 kDa |
Application
Antibody used in WB on Human Fetal liver at 1 ug/ml.
Application
Antibody used in IHC on Human Liver at 5.0 ug/ml.| Positive Control | 1) Cat. No. XBL-10409 - Fetal Liver Tissue Lysate |
|---|---|
| Application Notes | HSD11B1 antibody can be used for detection of HSD11B1 by ELISA at 1:312500. HSD11B1 antibody can be used for detection of HSD11B1 by western blot at 1 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.: |
| Form | Liquid |
|---|---|
| Storage Instructions | For short periods of storage (days) store at 4˚C. For longer periods of storage, store HSD11B1 antibody at -20˚C. As with any antibody avoid repeat freeze-thaw cycles. |
| Storage Buffer | Antibody is lyophilized in PBS buffer with 2% sucrose. Add 50 μL of distilled water. Final antibody concentration is 1 mg/mL. |
