Interleukin-1alpha is a member of the interleukin 1 cytokine family. It is a pleiotropic cytokine involved in various immune responses, inflammatory processes, and hematopoiesis. This cytokine is produced by monocytes and macrophages as a proprotein, which is proteolytically processed and released in response to cell injury, and thus induces apoptosis. IL-1 alpha and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. It has been suggested that the polymorphism of these genes is associated with rheumatoid arthritis and Alzheimer's disease.1) Du,Y.; et al. 2000. Neurology 55: 480-484.
Immunogen
Ni-NTA purified recombinant human IL-1α expressed in E. Coli strain BL21 (DE3).
Key Feature
Clonality
Monoclonal
Isotype
IgG2a
Host Species
Mouse
Tested Applications
ELISAWB
Western Blot:1:500 - 1,000 ELISA:Determining optimal working dilutions by titration test.:
Western blot analysis using IL - 1a monoclonal antibody against truncated IL - 1a recombinant protein.
Application Notes
Western Blot:1:500 - 1,000 ELISA:Determining optimal working dilutions by titration test.:
Additional Information
Form
Liquid
Storage Instructions
IL-1a monoclonal antibody can be stored at -20˚C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.