Interleukin-1 receptor type 2, IL-1R-2, IL-1RT-2, IL-1RT2, CD121 antigen-like family member B, CDw121b, IL-1 type II receptor, Interleukin-1 receptor beta, IL-1R-beta, Interleukin-1 receptor type II, CD121b, Interleukin-1 receptor type 2, membrane form, mI
Product description
The protein encoded by this gene is a cytokine receptor
that belongs to the interleukin 1 receptor family. This protein
binds interleukin alpha (IL1A), interleukin beta (IL1B), and
interleukin 1 receptor, type I(IL1R1/IL1RA), and acts as a decoy
receptor that inhibits the activity of its ligands. Interleukin 4
(IL4) is reported to antagonize the activity of interleukin 1 by
inducing the expression and release of this cytokine. This gene and
three other genes form a cytokine receptor gene cluster on
chromosome 2q12. Two alternatively spliced transcript variants
encoding the same protein have been reported.1) Giroux, S., et al. Bone 47(5):975-981(2010)
Immunogen
This IL1R2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 273-300 amino acids from the Central region of human IL1R2.
Interleukin-1 receptor type 2 IL-1R-2 IL-1RT-2 IL-1RT2 CD121 antigen-like family member B CDw121b IL-1 type II receptor Interleukin-1 receptor beta IL-1R-beta Interleukin-1 receptor type II CD121b Interleukin-1 receptor type 2 membrane form mI
Western blot analysis in WiDr cell line lysates (35ug/lane).
Application Notes
For WB starting dilution is: 1:1000:
Additional Information
Form
Liquid
Storage Instructions
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.