The protein encoded by this gene is a cytokine receptor that belongs to the interleukin 1 receptor family. This protein binds interleukin alpha (IL1A), interleukin beta (IL1B), and interleukin 1 receptor, type I(IL1R1/IL1RA), and acts as a decoy receptor that inhibits the activity of its ligands. Interleukin 4 (IL4) is reported to antagonize the activity of interleukin 1 by inducing the expression and release of this cytokine. This gene and three other genes form a cytokine receptor gene cluster on chromosome 2q12. Alternative splicing results in multiple transcript variants and protein isoforms. Alternative splicing produces both membrane-bound and soluble proteins. A soluble protein is also produced by proteolytic cleavage. [provided by RefSeq, May 2012]
Alternative Names
CD121b CDw121b IL 1R 2 IL 1R beta IL 1RT 2 IL 1RT2 IL1R2 IL1RB Interleukin 1 receptor beta Interleukin 1 receptor type 2 Interleukin 1 receptor type II
Molecular Weight(MW)
45 kDa
Cellular Localization
Cell membrane,Secreted.
Application
ICC/IF
Immunofluorescent analysis of (-20°C Ethanol) fixed HeLa cells using CoraLite®594-conjugated IL1R2 antibody at dilution of 1:100.
Application Notes
ICC/IF:1:50-1:500
Additional Information
Form
Liquid
Storage Instructions
Store at -20°C. Stable for one year after shipment.
Storage Buffer
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.