Application
Immunohistochemical analysis of paraffin - embedded human ovary tumor tissue (top) and testicle tumor tissue (bottom) showing cytoplasmic and membrane location using INHA antibody with DAB staining.Application
Immunohistochemical analysis of paraffin - embedded human lymphoid tissue showing cytoplasmic and membrane location using INHA antibody with DAB staining.| Product Name | INHA Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | Inhibin alpha chain |
| Product description | INHA(A-inhibin subunit precursor, inhibin alpha subunit ),also called inhibin(alpha) ,which is located on chromosome 2q33-q36. Inhibin is a gonadal protein that preferentially suppresses the secretion of pituitary follicle-stimulating hormone (FSH). Inhibin comprises of two subunits,Inhibin A and B. Inhibin has been shown to regulate gonadal stromal cell proliferation negatively and to have tumor suppressor activity. In addition, serum levels of inhibin have been shown to reflect the size of granulosa cell tumors and can therefore be used as a marker for primary as well as recurrent disease. In addition to their role in endocrine feedback in the reproductive sytem, inhibins subserve local regulatory roles in numerous extragonadal tissues, including brain, adrenal,bone marrow, placenta, and most notably anterior pituitary. Inhibin alpha subunit gene expression is down regulated in human prostate cancer, suggesting a tumor suppressive role.1) Mayo, K.E., Cerelli, G.M., Spiess, J., et al. 1986. Proc. Natl. Acad. Sci. USA 83: 5849-5853. |
| Immunogen | Ni-NTA purified truncated recombinant INHA expressed in E. Coli strain BL21 (DE3). |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG1 |
| Host Species | Mouse |
| Tested Applications | ELISAIHCWB |
| Western Blot:1:500 - 1:1,000 IHC(P):1:1,000 - 1:2,000 ELISA:Propose dilution 1:10,000 Determining optimal working dilutions by titration test.: |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | INHA |
|---|---|
| Alternative Names | Inhibin alpha chain |
Application
Immunohistochemical analysis of paraffin - embedded human ovary tumor tissue (top) and testicle tumor tissue (bottom) showing cytoplasmic and membrane location using INHA antibody with DAB staining.
Application
Immunohistochemical analysis of paraffin - embedded human lymphoid tissue showing cytoplasmic and membrane location using INHA antibody with DAB staining.| Application Notes | Western Blot:1:500 - 1:1,000 IHC(P):1:1,000 - 1:2,000 ELISA:Propose dilution 1:10,000 Determining optimal working dilutions by titration test.: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | INHA(Inhibin alpha) monoclonal antibody can be stored at -20˚C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. |
| Storage Buffer | Purified antibody in PBS containing 0.03% sodium azide |
