Application
Immunohistochemistry staining of IRAK2 in skin tissue using IRAK2 Antibody.| Product Name | IRAK2 Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | The binding of interleukin-1 (IL-1) to its receptor IL-1RI initiates a signaling cascade that results in the activation of NF-κB. Recently protein kinases designated IRAKs (IL-1 receptor-associated kinases) have been identified and designated as IRAK-1, IRAK-2 and IRAK-M. IRAK-2 is a serine/threonine protein kinase. The primary amino acid sequence of IRAK-2 shares similarity with that of Pelle, a protein kinase that is essential for the activation of a NF-κB homolog in Drosophila. IRAK (IL-1 receptor kinase) and mediates NF-κB activation by members of IL-1 family including IL-1 and a novel cytokine IL-18. Disruption of IRAK expression by anti-sense oligonucleotides inhibits IL-1 and IL-18-induced activation of NF-κB and activator protein, AP-1. IRAK2, an IRAK type protein kinase, is a signal transducer for the immune response interleukin-1 receptor (IL-1R) signaling cascade. IRAK2 also has been associated with signaling cell death, potentially via the Fas-associated death domain protein/caspase-8 apoptotic pathway. Dominant negative forms of IRAK2 attenuate IL-1R-mediated NF-kappa B activation, suggesting that IRAK-2 may serve as a therapeutic target for inhibiting IL-1-induced inflammation. |
| Immunogen | IRAK2 antibody was raised against a synthetic peptide of IRAK2 (Human). |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | IHCWB |
| IRAK2 antibody can be used in ELISA, Western Blot, immunohistochemistry starting at 5 μg/mL, and immunofluorescence starting at 10 μg/mL. | |
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Purification | Protein G |
| Gene Symbol | IRAK2 |
|---|---|
| Alternative Names | IRAK2 Il1rak2 IRAK-2 |
| Tissue Specificity | In Jurkat, a 67 kD band is observed. |
Application
Immunohistochemistry staining of IRAK2 in skin tissue using IRAK2 Antibody.| Application Notes | IRAK2 antibody can be used in ELISA, Western Blot, immunohistochemistry starting at 5 μg/mL, and immunofluorescence starting at 10 μg/mL. |
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| Form | Liquid |
|---|---|
| Storage Instructions | IRAK2 antibody can be stored short term 4 ˚C. For long term storage aliquot and store at -20 ˚C. As with all antibodies avoid freeze/thaw cycles. |
| Storage Buffer | PBS, 0.2% gelatin, 0.05% sodium azide. |
