The protein encoded by this gene hydrolyzes inosine
triphosphate and deoxyinosine triphosphate to the monophosphate
nucleotide and diphosphate. The encoded protein, which is a member
of the HAM1 NTPase protein family, is found in the cytoplasm and
acts as a homodimer. Defects in the encoded protein can result in
inosine triphosphate pyrophosphorylase deficiency. Two transcript
variants encoding two different isoforms have been found for this
gene. Also, at least two other transcript variants have been
identified which are probably regulatory rather than
protein-coding.1) Kim, J.H., et al. J. Clin. Gastroenterol. 44 (10), E242-E248 (2010) :
Immunogen
This ITPA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 149-178 amino acids from the C-terminal region of human ITPA.
Western blot analysis in MDA-MB453 cell line lysates (35ug/lane).
Application Notes
For WB starting dilution is: 1:1000:
Additional Information
Form
Liquid
Storage Instructions
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.