Application
Western blot analysis in mouse testis tissue lysates (35ug/lane).| Product Name | JARID1B Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | Lysine-specific demethylase 5B, 11411-, Cancer/testis antigen 31, CT31, Histone demethylase JARID1B, Jumonji/ARID domain-containing protein 1B, PLU-1, Retinoblastoma-binding protein 2 homolog 1, RBP2-H1, KDM5B, JARID1B, PLU1, RBBP2H1 |
| Product description | Histone demethylase that demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9' or H3 'Lys-27'. Demethylates trimethylated, dimethylated and monomethylated H3 'Lys-4'. Acts as a transcriptional corepressor for FOXG1B and PAX9. Favors the proliferation of breast cancer cells by repressing tumor suppressor genes such as BRCA1 and HOXA5. In contrast, may act as a tumor suppressor for melanoma.1) Kim, J., et al. Biochem. Biophys. Res. Commun. 401(3):412-416(2010) |
| Immunogen | This JARID1B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 192-224 amino acids from the N-terminal region of human JARID1B. |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WB |
| For WB starting dilution is: 1:1000: |
|
| Species Reactivity | Mouse |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | KDM5B |
|---|---|
| Alternative Names | Lysine-specific demethylase 5B 11411- Cancer/testis antigen 31 CT31 Histone demethylase JARID1B Jumonji/ARID domain-containing protein 1B PLU-1 Retinoblastoma-binding protein 2 homolog 1 RBP2-H1 KDM5B JARID1B PLU1 RBBP2H1 |
| Molecular Weight(MW) | 176 kDa |
Application
Western blot analysis in mouse testis tissue lysates (35ug/lane).| Application Notes | For WB starting dilution is: 1:1000: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. |
| Storage Buffer | Supplied in PBS with 0.09% (W/V) sodium azide. |
