| Product Name | Lipoma Preferred Partner Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | LPP; LIM Domain-containing Preferred Translocation Partner in Lipoma |
| Product description | Lipoma preferred partner (LPP) is encoded by the preferred fusion partner gene of the high mobility group protein HMGI-C. LPP is frequently affected by chromosomal translocations in a major group of soft tissue lipomas, as well as in a parosteal lipoma and in pulmonary chondroid hamartomas. The resulting fusion proteins comprise three DNA binding domains of HMGI-C fused to two or three C-terminal LIM domains of LPP and a reciprocal product, respectively. Expression of a HMGI-C/LPP fusion protein causes malignant transformation of fibroblasts. Similar to its relatives zyxin and TRIP (thyroid receptor interacting protein 6) / ZRP-1 (zyxin-related protein 1), LPP consists of a N-terminal proline-rich domain followed by three C-terminal LIM domains (double zinc finger structures that are involved in protein-protein interactions). Like the cytoskeletal protein zyxin, LPP localizes to focal adhesions and cell-cell adherens junctions. LPP harbors a nuclear export signal and displays transcriptional activation capacity. |
| Immunogen | Recombinant human lipoma preferred partner (LPP) (aa 1-109). |
| Clonality | Polyclonal |
|---|---|
| Host Species | Rabbit |
| Tested Applications | ICCIPWB |
| Immunocytochemistry: (1:500). Immunohistochemistry: (1:500). Western Blot: (1:1,000) . Optimal conditions must be determined individually for each application.: |
|
| Species Reactivity | HumanPigRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | LPP |
|---|---|
| Alternative Names | LPP LIM Domain-containing Preferred Translocation Partner in Lipoma |
| Tissue Specificity | Recognizes human, rat and pig LPP. |
| Entrez Gene | 4026 |
|---|---|
| Protein Accession | NP_001161143.1 |
| Application Notes | Immunocytochemistry: (1:500). Immunohistochemistry: (1:500). Western Blot: (1:1,000) . Optimal conditions must be determined individually for each application.: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Stable for at least 1 year after receipt when stored at -20˚C. |
| Storage Buffer | Liquid. In PBS containing 0.01% sodium azide. |
