MMP9, 92kd gelatinase, 92 kd type iv collagenase, 92 kDa gelatinase, 92 kDa type IV collagenase, Matrix metalloproteinase-9, MMP-9, Type V collagenase, CLG4B, Gelatinase B, GELB, Macrophage gelatinase, MANDP2
Product description
MMPs are a group of enzymes involved in matrix degradation. They share some important characteristics, such as a common mode of activation, a conserved amino acid sequence in the putative metal binding-active site region, and inhibition by specific proteinase inhibitors known as tissue inhibitors of metalloproteinases (TIMPs). Degradation of the extracellular matrix (ECM) is an essential step in tumor invasion and metastasis. The MMPs each have different substrate specificities within the ECM and are important in its degradation. MMP activity is dependent on the levels of activated MMP and TIMPs. MMP-9 is also known as collagenase IV or gelatinase B. Suitable for use in ELISA, Western Blot, Immunohistochemistry (FFPE) and Immunoprecipitation. Other applications not tested. Recognizes pro (latent) and activated forms of matrix metalloproteinase 9. Species Crossreactivity: Human and rat.
Immunogen
MMP9 monoclonal antibody was raised against purified human native MMP - 9. MW of Antigen: Pro form: 92kD Active form: ~86kD (Human).
Key Feature
Clonality
Monoclonal
Isotype
IgG1, k
Host Species
Mouse
Tested Applications
ELISAIHCIPWB
MMP9 antibody can be used in immunohistochemistry starting at 5 μg/mL.:
MMP9 92kd gelatinase 92 kd type iv collagenase 92 kDa gelatinase 92 kDa type IV collagenase Matrix metalloproteinase-9 MMP-9 Type V collagenase CLG4B Gelatinase B GELB Macrophage gelatinase MANDP2
Tissue Specificity
Recognizes pro (latent) and activated forms of matrix metalloproteinase 9.