Application
Immunohistochemistry staining of MYC in liver tissue using MYC monoclonal Antibody.| Product Name | MYC Antibody [9E10] |
|---|---|
| Antibody Type | Tags Antibodies |
| Product description | The antibody 9E10 may be used to detect the c-Myc tag. The c-myc gene (8q24 on human chromosome) is the cellular homologue of the v-myc gene originally isolated from an avian myelocytomatosis virus. The c-Myc protein is a transcription factor (nuclear localization). c-Myc is commonly activated in a variety of tumor cells and plays an important role in cellular proliferation, differentiation, apoptosis and cell cycle progression. The phosphorylation of c-Myc has been investigated and previous studies have suggested a functional association between phosphorylation at Thr58/Ser62 by glycogen synthase kinase 3, cyclin-dependent kinase, ERK2 and C-Jun N-terminal Kinase (JNK) in cell proliferation and cell cycle regulation. In normal cells the expression of c-Myc is tightly regulated but in human cancers c-Myc is frequently deregulated. c-Myc is also essential for tumor cell development in vasculogenesis and angiogenesis that distribute blood throughout the cells. |
| Immunogen | Synthetic peptide sequence (AEEQKLISEEDLL) corresponding to the C-terminal region of human c-myc. |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG1 |
| Host Species | Mouse |
| Tested Applications | FACSIHCIPWB |
| FACS (1 - 5 ug/ml), IHC-P (10 ug/ml), IP (1 - 5 ug/ml), WB (0.5 - 2 ug/ml) | |
| Species Reactivity | ChimpanzeeGorillaHuman |
| Concentration | 1mg/ml |
| Purification | Protein G |
| Gene Symbol | MYC tag |
|---|---|
| Alternative Names | MYC BHLHe39 C-Myc MRTL Myc proto-oncogene protein Proto-oncogene c-Myc Rats1 Transcription factor p64 v-myc |
| Tissue Specificity | The c-myc gene (8q24 on human chromosome) is the cellular homologue of the v-myc gene originally isolated from an avian myelocytomatosis virus. |
Application
Immunohistochemistry staining of MYC in liver tissue using MYC monoclonal Antibody.| Application Notes | FACS (1 - 5 ug/ml), IHC-P (10 ug/ml), IP (1 - 5 ug/ml), WB (0.5 - 2 ug/ml) |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Store MYC antibody at 4 ˚C or -20 ˚C. As with all antibodies avoid freeze/thaw cycles. |
| Storage Buffer | PBS, 15 mM sodium azide, approx., pH 7.4. |
