Inhibition of NFkappa-B activity by the hepatitis C virus core protein might be related to its physical interaction with and interrupted nuclear localization of IKKbeta. Increased nuclear factor-kappaB (NF-kB) activity in the amnion during labor is associated with an increase in the expression of NF-kBp65 and of the NF-kB binding proteins IkBa, IkBb-1 and IkBb-2. IkappaBbeta may be a novel target for transcription factors of the HMG-box SRY/Sox family and imply a potential role for NF-kappaB/IkappaBbeta in spermatogenesis.1) Lee, Y., et al., (2003) Mol. Hum. Reprod. 9 (4), 213-218.
Immunogen
Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human NFKBIB.
Key Feature
Clonality
Polyclonal
Host Species
Rabbit
Tested Applications
WB
NFKBIB antibody can be used for detection of NFKBIB by ELISA at 1:62500. NFKBIB antibody can be used for detection of NFKBIB by western blot at 1.25 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.:
NFKBIB antibody can be used for detection of NFKBIB by ELISA at 1:62500. NFKBIB antibody can be used for detection of NFKBIB by western blot at 1.25 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.:
Additional Information
Form
Liquid
Storage Instructions
For short periods of storage (days) store at 4˚C. For longer periods of storage, store NFKBIB antibody at -20˚C. As with any antibody avoid repeat freeze-thaw cycles.
Storage Buffer
IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt