Application
Immunohistochemistry staining of NFKBIB in small intestine, peyer's patch tissue using NFKBIB Antibody.| Product Name | NFKBIB Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | NFKBIB, IKBB, I-kappa-B-beta, IkappaBbeta, NF-kappa-B inhibitor beta, IkB-beta, TRIP9, TRIP-9, IkB-B, NF-kappa-BIB, TR-interacting protein 9 |
| Product description | NFκB was originally identified as a factor that binds to the immunoglobulin kappa light chain enhancer in B cells. It was subsequently found in non-B cells in an inactive cytoplasmic form consisting of NFκB bound to IkB. NFκB was originally identified as a heterodimeric DNA binding protein complex consisting of p65 (RelA) and p50 (NFκB1) subunits. Other identified subunits include p52 (NFκB2), c-Rel, and RelB. The p65, cRel, and RelB subunits are responsible for transactivation. The p50 and p52 subunits possess DNA binding activity but limited ability to transactivate. p52 has been reported to form transcriptionally active heterodimers with the NFκB subunit p65, similar to p50/p65 heterodimers. The heterodimers of p52/p65 and p50/p65 are regulated by physical inactivation in the cytoplasm by IkB-a. IkB-a binds to the p65 subunit, preventing nuclear localization and DNA binding. Low levels of p52 and p50 homodimers can also exist in cells. |
| Immunogen | NFKBIB antibody was raised against amino acids 1 - 19 of NFKBIB (Human). |
| Clonality | Polyclonal |
|---|---|
| Host Species | Rabbit |
| Tested Applications | ELISAIFIHCIPWB |
| NFKBIB antibody can be used in immunohistochemistry starting at 10 μg/mL.: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | NFKBIB |
|---|---|
| Alternative Names | NFKBIB IKBB I-kappa-B-beta IkappaBbeta NF-kappa-B inhibitor beta IkB-beta TRIP9 TRIP-9 IkB-B NF-kappa-BIB TR-interacting protein 9 |
Application
Immunohistochemistry staining of NFKBIB in small intestine, peyer's patch tissue using NFKBIB Antibody.| Application Notes | NFKBIB antibody can be used in immunohistochemistry starting at 10 μg/mL.: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Store NFKBIB antibody at -20 ˚C or below prior to opening. Dilute only prior to immediate use. Aliquot contents and freeze at -20 ˚C or below. As with all antibodies avoid freeze/thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
