Tonsoku-like protein, Inhibitor of kappa B-related protein, I-kappa-B-related protein, IkappaBR, NF-kappa-B inhibitor-like protein 2, Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 2, TONSL, IKBR, NFKBIL2
Product description
The protein encoded by this gene is thought to be a
negative regulator of NF-kappa-B mediated transcription. The
encoded protein may bind NF-kappa-B complexes and trap them in the
cytoplasm, preventing them from entering the nucleus and
interacting with the DNA. Phosphorylation of this protein targets
it for degradation by the ubiquitination pathway, which frees the
NF-kappa-B complexes to enter the nucleus.1) Wang, Y., et al. J. Hum. Genet. 55(8):490-494(2010)
Immunogen
This NFKBIL2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 38-65 amino acids from the N-terminal region of human NFKBIL2.
Tonsoku-like protein Inhibitor of kappa B-related protein I-kappa-B-related protein IkappaBR NF-kappa-B inhibitor-like protein 2 Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 2 TONSL IKBR NFKBIL2
Western blot analysis in MDA-MB453 cell line lysates (35ug/lane).
Application Notes
For WB starting dilution is: 1:1000:
Additional Information
Form
Liquid
Storage Instructions
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.