Application
Immunohistochemistry staining of NKIRAS1 in breast tissue using NKIRAS1 monoclonal Antibody.| Product Name | NKIRAS1 Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | NKIRAS1, Kappa B-Ras protein 1, Kappa B-ras 1, KappaB-Ras1, KBRAS1 |
| Product description | NF-κB is silenced in the cytoplasm by an inhibitory protein, IkB. Synthesis of IkBa is autoregulated. IkB proteins are phosphorylated by IkB kinase complex consisting of at least three proteins, IKK1/a, IKK2/b, and IKK3/g (3-6). External stimuli such as tumor necrosis factor or other cytokines results in phosphorylation and degradation of IkB releasing NF-κB dimers. NF-κB dimer subsequently translocates to the nucleus and activates target genes. Six members of IkB family members have been identified. One of the first genes induced following NF-κB activation is IkBa. Recently, two proteins, kB-Ras1 and kB-Ras2 have been identified. These two proteins interact with PEST domains of IkBa and IkBb and decrease their rate of degradation. |
| Immunogen | NKIRAS1 monoclonal antibody was raised against amino acids 96 - 113 of NKIRAS1 (Human). |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG1 |
| Host Species | Mouse |
| Tested Applications | IHCWB |
| NKIRAS1 antibody can be used in ELISA, Western Blot starting at 1:500 - 1:1000, immunohistochemistry starting at 5 μg/mL, and immunofluorescence starting at 10 μg/mL.: |
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| Species Reactivity | DogGibbonGoatGorillaHamsterHorseHumanMonkeyMouseRabbitRat |
| Concentration | 1mg/ml |
| Purification | Protein G |
| Gene Symbol | NKIRAS1 |
|---|---|
| Alternative Names | NKIRAS1 Kappa B-Ras protein 1 Kappa B-ras 1 KappaB-Ras1 KBRAS1 |
Application
Immunohistochemistry staining of NKIRAS1 in breast tissue using NKIRAS1 monoclonal Antibody.| Application Notes | NKIRAS1 antibody can be used in ELISA, Western Blot starting at 1:500 - 1:1000, immunohistochemistry starting at 5 μg/mL, and immunofluorescence starting at 10 μg/mL.: |
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| Form | Liquid |
|---|---|
| Storage Instructions | NKIRAS1 antibody can be stored short term 4 ˚C. For long term storage aliquot and store at -20 ˚C. As with all antibodies avoid freeze/thaw cycles. |
| Storage Buffer | PBS, 0.02% sodium azide. |
